Incidence of atrioventricular block with vasodilator stress SPECT: A meta-analysis.
J Nucl Cardiol
; 26(2): 616-628, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-29043556
ABSTRACT
BACKGROUND:
Adenosine or regadenoson are often used with pharmacologic stress testing. Adenosine may trigger atrioventricular block (AVB). Despite its higher selectivity, regadenoson has also been associated with AVB. We studied the incidence of de novo AVB with these agents.METHODS:
A comprehensive search of SCOPUS was performed from inception to March 2016. Studies of at least 10 patients, using adenosine and/or regadenoson with SPECT-MPI, reporting rates of AVB were selected for further review.RESULTS:
Thirty four studies were pooled including 22,957 patients. Adenosine was used in 21 studies and regadenoson in 15. Both were administered in two studies. The estimated incidence of overall and high-grade AVB was 3.81% (95% CI 1.99%-6.19%) and 1.93% (95% CI 0.77%-3.59%), respectively. The incidence of AVB (8.58%; 95% CI 5.55%-12.21% vs 0.30%; 95% CI 0.04%-0.82%, respectively, P < .001) and high-grade AVB (5.21%; 95% CI 2.81%-8.30% vs 0.05%; 95% CI < .001%-0.19% respectively, P < .001) were higher with adenosine compared to regadenoson.CONCLUSION:
AVB is seen in about 4% of patients undergoing vasodilator stress test. Both overall and high-grade AVB are more frequent with adenosine compared to regadenoson.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Purinas
/
Pirazóis
/
Doença da Artéria Coronariana
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Adenosina
/
Teste de Esforço
/
Bloqueio Atrioventricular
Tipo de estudo:
Incidence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Nucl Cardiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos