RRM2B: An oxygen-requiring protein with a role in hypoxia.
Mol Cell Oncol
; 4(5): e1335272, 2017.
Article
em En
| MEDLINE
| ID: mdl-29057303
ABSTRACT
How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B. This property of RNR is essential for hypoxic cell viability and therefore contributes to the most aggressive and therapy-resistant fraction of tumors.
Texto completo:
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido