Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen <i>Streptococcus pyogenes</i>.

Blom, Anna M; Magda, Michal; Kohl, Lisa; Shaughnessy, Jutamas; Lambris, John D; Ram, Sanjay; Ermert, David

Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes.

Blom, Anna M; Magda, Michal; Kohl, Lisa; Shaughnessy, Jutamas; Lambris, John D; Ram, Sanjay; Ermert, David.

Afiliação

Blom AM; Department of Translational Medicine, Medical Protein Chemistry, Lund University, Skåne County Council, Malmö 20502, Sweden.
Magda M; Department of Translational Medicine, Medical Protein Chemistry, Lund University, Skåne County Council, Malmö 20502, Sweden.
Kohl L; Department of Translational Medicine, Medical Protein Chemistry, Lund University, Skåne County Council, Malmö 20502, Sweden.
Shaughnessy J; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605; and.
Lambris JD; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ram S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605; and.
Ermert D; Department of Translational Medicine, Medical Protein Chemistry, Lund University, Skåne County Council, Malmö 20502, Sweden; David.Ermert@med.lu.se.

J Immunol ; 199(11): 3828-3839, 2017 12 01.

Article em En | MEDLINE | ID: mdl-29084837

Assuntos

Fator H do Complemento/uso terapêutico; Imunoterapia/métodos; Proteínas Recombinantes de Fusão/uso terapêutico; Sepse/terapia; Vacinas Antiestafilocócicas/imunologia; Infecções Estreptocócicas/terapia; Streptococcus pyogenes/imunologia; Animais; Antibacterianos/uso terapêutico; Células Cultivadas; Complemento C3/metabolismo; C3 Convertase da Via Alternativa do Complemento; Fator H do Complemento/genética; Resistência a Múltiplos Medicamentos; Humanos; Camundongos; Camundongos Transgênicos; Fagocitose; Proteínas Recombinantes de Fusão/genética; Sepse/imunologia; Infecções Estreptocócicas/imunologia

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções Estreptocócicas / Streptococcus pyogenes / Proteínas Recombinantes de Fusão / Vacinas Antiestafilocócicas / Fator H do Complemento / Sepse / Imunoterapia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Immunol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia

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