Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis.

Chan, Shing; Lian, Qizhou; Chen, Mei-Pian; Jiang, Dan; Ho, Jolie T K; Cheung, Yiu-Fai; Chan, Godfrey Chi-Fung

Chan, Shing; Lian, Qizhou; Chen, Mei-Pian; Jiang, Dan; Ho, Jolie T K; Cheung, Yiu-Fai; Chan, Godfrey Chi-Fung.

Afiliação

Chan S; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Lian Q; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Chen MP; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Jiang D; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Ho JTK; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Cheung YF; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Chan GC; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: gcfchan@hku.hk.

Toxicol Appl Pharmacol ; 338: 148-158, 2018 01 01.

Article em En | MEDLINE | ID: mdl-29132816

Assuntos

Apoptose/efeitos dos fármacos; Micropartículas Derivadas de Células/efeitos dos fármacos; Células Endoteliais/efeitos dos fármacos; Sobrecarga de Ferro/complicações; Mitocôndrias/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Piridonas/farmacologia; Tromboplastina/análise; Trifosfato de Adenosina/biossíntese; Micropartículas Derivadas de Células/fisiologia; Células Cultivadas; Deferiprona; Humanos; Sobrecarga de Ferro/metabolismo; Sobrecarga de Ferro/patologia; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Apoptosis; Endothelial microparticles; Iron; L1; Mitochondria; Oxidative stress; Tissue factor

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piridonas / Tromboplastina / Apoptose / Estresse Oxidativo / Sobrecarga de Ferro / Células Endoteliais / Micropartículas Derivadas de Células / Mitocôndrias Limite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2018 Tipo de documento: Article

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