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Subcellular localization of ß-arrestin1 and its prognostic value in lung adenocarcinoma.
Li, Xiaowei; Che, Keying; Wang, Liguang; Zhang, Tiehong; Wang, Guanghui; Pang, Zhaofei; Shen, Hongchang; Du, Jiajun.
Afiliação
  • Li X; Institute of Oncology Department of Anesthesiology Department of Oncology Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China.
Medicine (Baltimore) ; 96(45): e8450, 2017 Nov.
Article em En | MEDLINE | ID: mdl-29137031
ß-Arrestins play important roles in cancer progression, and the subcellular localization of ß-arrestin1 has been receiving increasingly more attention. Intriguingly, several studies, including some of our previous work, showed that the effects of ß-arrestin1 on outcomes of cancer patients were controversial.Specimens were obtained from 133 patients with lung adenocarcinoma. Immunohistochemistry was used to detect the expression of ß-arrestin1 and p300 in the collected tissues. The Kaplan-Meier analysis and Cox proportional hazards regression were used to examine the relationship between ß-arrestin1 and patient survival.We found no significant association between ß-arrestin1 and clinicopathological variables. The Kaplan-Meier plot showed that patients with high expression of ß-arrestin1 (especially in the nucleus) had a poorer overall survival (OS) and shorter disease-free survival (DFS) (P = .026, P = .015). Additionally, high p300 expression also resulted in worse OS (P = .039). Following the univariate analysis, high expressions of nuclear ß-arrestin1 and p300 were classed as poor prognostic factors for both OS (P = .016) and DFS (P = .025).The expression of ß-arrestin1 in the nucleus is associated with increased malignant tendency of lung adenocarcinoma, and the predictive value of ß-arrestin1 may be optimized by combining information about the expression of p300 acetyltransferase.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteína p300 Associada a E1A / Beta-Arrestina 1 / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteína p300 Associada a E1A / Beta-Arrestina 1 / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2017 Tipo de documento: Article