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Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.
Chen, Jun; Peng, Zhangzhe; Lu, Miaomiao; Xiong, Xuan; Chen, Zhuo; Li, Qianbin; Cheng, Zeneng; Jiang, Dejian; Tao, Lijian; Hu, Gaoyun.
Afiliação
  • Chen J; Department of Medicinal Chemistry, Xiangya School of Pharmacy, Central South University, Changsha 410013, China.
  • Peng Z; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Lu M; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Xiong X; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Chen Z; Department of Medicinal Chemistry, Xiangya School of Pharmacy, Central South University, Changsha 410013, China.
  • Li Q; Department of Medicinal Chemistry, Xiangya School of Pharmacy, Central South University, Changsha 410013, China.
  • Cheng Z; Department of Medicinal Chemistry, Xiangya School of Pharmacy, Central South University, Changsha 410013, China.
  • Jiang D; Drug Safety Evaluation Research Center of Hunan Province, Changsha 410331, China.
  • Tao L; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Hu G; Department of Medicinal Chemistry, Xiangya School of Pharmacy, Central South University, Changsha 410013, China. Electronic address: hugaoyun@csu.edu.cn.
Bioorg Med Chem Lett ; 28(2): 222-229, 2018 01 15.
Article em En | MEDLINE | ID: mdl-29248299
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Piridonas / Anti-Inflamatórios não Esteroides / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Descoberta de Drogas / Hipoglicemiantes / Falência Renal Crônica Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Piridonas / Anti-Inflamatórios não Esteroides / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Descoberta de Drogas / Hipoglicemiantes / Falência Renal Crônica Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China