NAT1 genotypic and phenotypic contribution to urinary bladder cancer risk: a systematic review and meta-analysis.
Drug Metab Rev
; 50(2): 208-219, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29258340
ABSTRACT
N-acetyltransferase 1 (NAT1), a polymorphic Phase II enzyme, plays an essential role in metabolizing heterocyclic and aromatic amines, which are implicated in urinary bladder cancer (BCa). This systematic review investigates a possible association between the different NAT1 genetic polymorphisms and BCa risk. Medline, PubMed, EMBASE, Scopus, Web of Science, OpenGrey, and BASE databases were searched to identify eligible studies. The random-effect model was used to calculate pooled effects estimates. Statistical heterogeneity was tested with Chi-square and I2. Twenty case-control studies, including 5606 cases and 6620 controls, met the inclusion criteria. Pooled odds ratios (OR) analyses showed a statistically significant difference in NAT1*10 versus non-NAT1*10 acetylators in the total sample (OR 0.87; 95% CI 0.79-0.96) but was borderline among Caucasians (OR 0.88 with 95% CI 0.77-1.01). No statistically significant differences in BCa risk were found for NAT1*10 versus NAT1*4 wild type (OR 0.97; 95% CI 0.78-1.19), NAT1 'Fast' versus 'Normal' acetylators (OR 1.03; 95% CI 0.84-1.27), and NAT1 'Slow' versus 'Fast' (OR 2.32; 95% CI 0.93-5.84) or 'Slow' versus 'Normal' acetylators (OR 1.84; 95% CI 0.92-3.68). When stratifying by smoking status, no statistically significant differences in BCa risk were found for NAT1*10 versus non-NAT1*10 acetylators among the different subgroups. Our study suggests a modest protective role for NAT1*10 and a possible risk contributory role for slow acetylation genotypes in BCa risk. Further research is recommended to confirm these associations.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Arilamina N-Acetiltransferase
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Neoplasias da Bexiga Urinária
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Isoenzimas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Drug Metab Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Líbano