Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARÎ³/RXR and RAR/RXR: down-regulation of CYP27A1-LXR&#945; signaling.

Mangum, Lee C; Hou, Xiang; Borazjani, Abdolsamad; Lee, Jung Hwa; Ross, Matthew K; Crow, J Allen

Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARÎ³/RXR and RAR/RXR: down-regulation of CYP27A1-LXRα signaling.

Mangum, Lee C; Hou, Xiang; Borazjani, Abdolsamad; Lee, Jung Hwa; Ross, Matthew K; Crow, J Allen.

Afiliação

Mangum LC; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, U.S.A.
Hou X; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, U.S.A.
Borazjani A; Jiangsu Academy of Agricultural Sciences, Institute of Food Safety, Nanjing, China.
Lee JH; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, U.S.A.
Ross MK; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, U.S.A.
Crow JA; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, U.S.A. mross@cvm.msstate.edu crow@cvm.msstate.edu.

Biochem J ; 475(3): 621-642, 2018 02 09.

Article em En | MEDLINE | ID: mdl-29321244

Assuntos

Transportador 1 de Cassete de Ligação de ATP/genética; Hidrolases de Éster Carboxílico/genética; Colestanotriol 26-Mono-Oxigenase/genética; Colesterol/metabolismo; Receptores X do Fígado/genética; Antígenos CD36/genética; Hidrolases de Éster Carboxílico/antagonistas & inibidores; Linhagem Celular; Células Espumosas/metabolismo; Regulação da Expressão Gênica; Inativação Gênica; Humanos; Macrófagos/metabolismo; PPAR gama/genética; PPAR gama/metabolismo; Receptor alfa de Ácido Retinoico/genética; Receptor X Retinoide alfa/genética; Receptores Depuradores Classe A/genética

Palavras-chave

2-arachidonoylglycerol; PPARÎ³; RXR; carboxylesterase; cholesterol; macrophage

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Hidrolases de Éster Carboxílico / Colesterol / Colestanotriol 26-Mono-Oxigenase / Transportador 1 de Cassete de Ligação de ATP / Receptores X do Fígado Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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