Can CT-based radiomics signature predict KRAS/NRAS/BRAF mutations in colorectal cancer?
Eur Radiol
; 28(5): 2058-2067, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29335867
ABSTRACT
OBJECTIVES:
To investigate whether CT-based radiomics signature can predict KRAS/NRAS/BRAF mutations in colorectal cancer (CRC).METHODS:
This retrospective study consisted of a primary cohort (n = 61) and a validation cohort (n = 56) with pathologically confirmed CRC. Patients underwent KRAS/NRAS/BRAF mutation tests and contrast-enhanced CT before treatment. A total of 346 radiomics features were extracted from portal venous-phase CT images of the entire primary tumour. Associations between the genetic mutations and clinical background, tumour staging, and histological differentiation were assessed using univariate analysis. RELIEFF and support vector machine methods were performed to select key features and build a radiomics signature.RESULTS:
The radiomics signature was significantly associated with KRAS/NRAS/BRAF mutations (P < 0.001). The area under the curve, sensitivity, and specificity for predicting KRAS/NRAS/BRAF mutations were 0.869, 0.757, and 0.833 in the primary cohort, respectively, while they were 0.829, 0.686, and 0.857 in the validation cohort, respectively. Clinical background, tumour staging, and histological differentiation were not associated with KRAS/NRAS/BRAF mutations in both cohorts (P>0.05).CONCLUSIONS:
The proposed CT-based radiomics signature is associated with KRAS/NRAS/BRAF mutations. CT may be useful for analysis of tumour genotype in CRC and thus helpful to determine therapeutic strategies. KEY POINTS ⢠Key features were extracted from CT images of the primary colorectal tumour. ⢠The proposed radiomics signature was significantly associated with KRAS/NRAS/BRAF mutations. ⢠In the primary cohort, the proposed radiomics signature predicted mutations. ⢠Clinical background, tumour staging, and histological differentiation were unable to predict mutations.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Tomografia Computadorizada por Raios X
/
Proteínas Proto-Oncogênicas p21(ras)
/
Proteínas Proto-Oncogênicas B-raf
/
GTP Fosfo-Hidrolases
/
Proteínas de Membrana
/
Mutação
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China