Dihydrotestosterone Treatment Accelerates Autograft Reversal Sciatic Nerve Regeneration in Rats.
Neurochem Res
; 43(3): 659-668, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29340845
ABSTRACT
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation. Sprague-Dawley rats were subjected to a 10-mm right side sciatic nerve reversed autologous nerve transplantation and randomly divided into groups that received DHT or DHT + flutamide (an androgen receptor blocker) daily for 8 weeks after operation. Our results demonstrated that DHT could speed up the rate of axonal regeneration and increase the expression of myelin protein zero (P0) in autograft reversal sciatic nerves. Thus, our study provided new insights into improving the prognosis of patients with long gap peripheral nerve defects.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Di-Hidrotestosterona
/
Autoenxertos
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China