Acute postprandial lipaemia does not influence the in vivo activity of human platelets.
Thromb Res
; 39(6): 725-32, 1985 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-2934861
ABSTRACT
Platelet function and serum lipid studies were conducted on nine healthy male subjects before and two hours after three separate meals, two of which were rich in fat saturated fat (SF) or polyunsaturated fat (PUF), and a third control meal which contained no fat. Platelet activity was assessed by determination of in vivo platelet aggregate formation, and plasma levels of the platelet specific proteins platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG). Serum triglyceride levels increased significantly after both fat containing meals but were unaffected by the fat free meal. Serum cholesterol levels were not affected by any of the three meals. Platelet function tests could not detect any alteration of in vivo platelet activity in terms of platelet aggregate formation or plasma concentrations of PF4 and beta-TG. These results are at variance with previously published studies that used less specific assays of platelet activity and which suggested platelet activation shortly after meals rich in SF.
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Bases de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Gorduras na Dieta
/
Lipídeos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Thromb Res
Ano de publicação:
1985
Tipo de documento:
Article