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Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery.
Grégoire, Matthieu; Libois, Julia Brochard; Waast, Denis; Gaborit, Benjamin; Dauty, Marc; Deslandes, Guillaume; Dailly, Eric; Touchais, Sophie; Boutoille, David; Grégoire, Nicolas; Couet, William.
Afiliação
  • Grégoire M; Clinical Pharmacology Department, CHU Nantes, Nantes, France matthieu.gregoire@chu-nantes.fr.
  • Libois JB; UMR INSERM 1235, The Enteric Nervous System in Gut and Brain Disorders, University of Nantes, Nantes, France.
  • Waast D; Infectious Diseases Department, CHU Nantes and CIC 1413, INSERM, Nantes, France.
  • Gaborit B; Trauma and Orthopedics Department, CHU Nantes, Nantes, France.
  • Dauty M; Infectious Diseases Department, CHU Nantes and CIC 1413, INSERM, Nantes, France.
  • Deslandes G; EA 3826 Thérapeutiques Cliniques et Expérimentales des Infections, University of Nantes, Nantes, France.
  • Dailly E; Physical and Rehabilitation Medicine Department, CHU Nantes, Nantes, France.
  • Touchais S; Clinical Pharmacology Department, CHU Nantes, Nantes, France.
  • Boutoille D; Clinical Pharmacology Department, CHU Nantes, Nantes, France.
  • Grégoire N; EE1701 Microbiotas, Hosts, Antibiotics and Bacterial Resistances, University of Nantes, Nantes, France.
  • Couet W; Trauma and Orthopedics Department, CHU Nantes, Nantes, France.
Antimicrob Agents Chemother ; 62(4)2018 04.
Article em En | MEDLINE | ID: mdl-29378714
ABSTRACT
An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC0-24) was 28.3 mg/liter · h. The AUC0-24/MIC ratio for unbound concentrations and for sensitive Staphylococcus and Streptococcus strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tetrazóis / Oxazolidinonas / Cirurgia Bariátrica / Obesidade Limite: Aged / Female / Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tetrazóis / Oxazolidinonas / Cirurgia Bariátrica / Obesidade Limite: Aged / Female / Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França