Knockout of Toll-like receptor 4 improves survival and cardiac function in a murine model of severe sepsis.

Zhou, Dan; Zhu, Yun; Ouyang, Min-Zhi; Zhang, Ming; Tang, Kui; Niu, Cheng-Cheng; Li, Ling

Zhou, Dan; Zhu, Yun; Ouyang, Min-Zhi; Zhang, Ming; Tang, Kui; Niu, Cheng-Cheng; Li, Ling.

Afiliação

Zhou D; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zhu Y; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Ouyang MZ; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zhang M; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Tang K; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Niu CC; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Li L; Medical Basic Teaching Experiment Center, College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.

Mol Med Rep ; 17(4): 5368-5375, 2018 04.

Article em En | MEDLINE | ID: mdl-29393431

Assuntos

Sepse/genética; Sepse/mortalidade; Receptor 4 Toll-Like/deficiência; Função Ventricular/genética; Animais; Apoptose; Biomarcadores; Citocinas/metabolismo; Modelos Animais de Doenças; Ecocardiografia; Testes de Função Cardíaca; Mediadores da Inflamação/metabolismo; Masculino; Camundongos; Camundongos Knockout; Fator 88 de Diferenciação Mieloide/metabolismo; Miocárdio/metabolismo; Miocárdio/patologia; NF-kappa B/genética; NF-kappa B/metabolismo; Infiltração de Neutrófilos/imunologia; Neutrófilos/imunologia; Neutrófilos/metabolismo; Sepse/diagnóstico; Índice de Gravidade de Doença; Taxa de Sobrevida

Palavras-chave

toll-like receptor 4; sepsis; myocardial dysfunction; inflammation response; apoptosis

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Função Ventricular / Sepse / Receptor 4 Toll-Like Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Mol Med Rep Ano de publicação: 2018 Tipo de documento: Article

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