No Effect of Adjunctive Minocycline Treatment on Body Metabolism in Patients With Schizophrenia.
J Clin Psychopharmacol
; 38(2): 125-128, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29424804
ABSTRACT
PURPOSE/BACKGROUND:
This study examined the effect of adjunctive minocycline on body metabolism in risperidone-treated patients with schizophrenia. METHODS/PROCEDURES Each subject had a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of schizophrenia and had been on stable dose of risperidone for at least 4 weeks. In a 16-week randomized, double-blind, placebo-controlled study, subjects received either minocycline (200 mg/d) or placebo. Various metabolic parameters, including weight, waist circumference, fasting insulin, glucose, and lipids, were measured at baseline and week 16. FINDINGS/RESULTS:
A total of 63 subjects with schizophrenia were enrolled in the study. Fifty-five patients completed week-16 assessments (27 in the minocycline group, 28 in the placebo group). There were no significant differences between the 2 groups in week 16 changes for body weight, body mass index, waist circumference, fasting insulin, glucose, and lipids (P's > 0.300). IMPLICATIONS/CONCLUSIONS:
In the present study, adjunctive treatment of minocycline did not seem to improve body metabolism in patients with schizophrenia receiving risperidone. The implications for future studies were discussed.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Avaliação de Resultados em Cuidados de Saúde
/
Risperidona
/
Inflamação
/
Anti-Inflamatórios
/
Minociclina
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Psychopharmacol
Ano de publicação:
2018
Tipo de documento:
Article