Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours.
Anticancer Res
; 38(3): 1343-1352, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29491058
ABSTRACT
BACKGROUND/AIM:
The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. MATERIALS ANDMETHODS:
We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA).RESULTS:
HNSCC tumours express high levels of SERPINB3/B4 mRNA. SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread. Interestingly, we observed an association between SERPINB3/B4 and the presence of tumour immune infiltrate as well as the expression of the immune checkpoint regulators PD-L1/PD-L2 that depended on HPV status.CONCLUSION:
Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Serpinas
/
Neoplasias de Cabeça e Pescoço
/
Antígenos de Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França