Dihydroorotate Dehydrogenase as a Target for the Development of Novel Helicobacter pylori-Specific Antimicrobials.
Chem Pharm Bull (Tokyo)
; 66(3): 239-242, 2018.
Article
em En
| MEDLINE
| ID: mdl-29491257
ABSTRACT
Helicobacter pylori (H. pylori) infection is the world's most common bacterial infection, affecting approximately 50% of the global population. H. pylori is the strongest known risk factor for stomach diseases, including cancer. Hence, treatment for H. pylori infection can help reduce the risk of these diseases. However, the emergence of drug-resistant strains of H. pylori and the occurrence of adverse effects resulting from current therapies have complicated the successful eradication of H. pylori infection. Although various antibiotics that target several bacterial enzymes have been discovered, dihydroorotate dehydrogenase (DHODH) may hold potential for the development of novel anti-H. pylori agents with reduced toxicity and side effects. Here we review the existing literature that has focused on strategies for developing novel therapeutic agents that target the DHODH of H. pylori.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
/
Oxirredutases atuantes sobre Doadores de Grupo CH-CH
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Inibidores Enzimáticos
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Antibacterianos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2018
Tipo de documento:
Article