Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury.
Blood
; 131(18): 2001-2006, 2018 05 03.
Article
em En
| MEDLINE
| ID: mdl-29507078
ABSTRACT
Traumatic brain injury (TBI)-induced coagulopathy is a common and well-recognized risk for poor clinical outcomes, but its pathogenesis remains poorly understood, and treatment options are limited and ineffective. We discuss the recent progress and knowledge gaps in understanding this lethal complication of TBI. We focus on (1) the disruption of the brain-blood barrier to disseminate brain injury systemically by releasing brain-derived molecules into the circulation and (2) TBI-induced hypercoagulable and hyperfibrinolytic states that result in persistent and delayed intracranial hemorrhage and systemic bleeding.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Lesões Encefálicas Traumáticas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China