The prognostic significance of tumor-infiltrating lymphocytes for primary melanoma varies by sex.
J Am Acad Dermatol
; 79(2): 245-251, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29518458
ABSTRACT
BACKGROUND:
The immune response to melanoma is manifested locally by tumor-infiltrating lymphocytes (TILs). Men and women are known to have varying patterns of immunity, yet sex-specific prognostic implications of TILs have not been explored.METHODS:
Patients who had clinically localized primary melanoma with a Breslow thickness of 0.76 mm or more and underwent sentinel lymph node (SLN) biopsy at our institution were identified. The association between TILs (absent, nonbrisk, and brisk) and SLN positivity was evaluated by using logistic regression. Overall survival (OS) was evaluated by TIL status and sex.RESULTS:
Among 1367 patients identified, 794 were men. TILs were brisk in 143 lesions, nonbrisk in 903, and absent in 321, which did not vary by sex (P = .71). SLN positivity was associated with TILs among men (brisk, 3.8%; nonbrisk, 16.9%; and absent, 26.6% [P < .001]). In contrast, there was no association between SLN positivity and TILs among women (P = .49). Interaction between brisk TILs and sex on SLN positivity was significant (P = .029). Among men, presence of brisk TILs was associated with prolonged OS (P = .038) but not after adjustment for SLN status (P = .42). There was no association between TIL status and OS among women.LIMITATIONS:
Findings from this single-institution study have yet to be validated by other research groups.CONCLUSIONS:
The implications of TILs in predicting SLN positivity appear to be more relevant for men than for women.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Linfócitos do Interstício Tumoral
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Melanoma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2018
Tipo de documento:
Article