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Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.
Pognan, Francois; Mahl, J Andreas; Papoutsi, Maria; Ledieu, David; Raccuglia, Marc; Theil, Diethilde; Voytek, Sarah B; Devine, Patrick J; Kubek-Luck, Katie; Claudio, Natalie; Cordier, Andre; Heier, Annabelle; Kolly, Carine; Hartmann, Andreas; Chibout, Salah-Dine; Bouchard, Page; Trendelenburg, Christian.
Afiliação
  • Pognan F; Preclinical Safety, Novartis, Basel, Switzerland. Francois.pognan@novartis.com.
  • Mahl JA; Discovery Investigative Safety, Preclinical Safety, Novartis, Klybeckstrasse 141, 4057, Basel, Switzerland. Francois.pognan@novartis.com.
  • Papoutsi M; Preclinical Safety, Novartis, Basel, Switzerland.
  • Ledieu D; Preclinical Safety, Novartis, Basel, Switzerland.
  • Raccuglia M; Preclinical Safety, Novartis, Basel, Switzerland.
  • Theil D; Pharmacokinetics Sciences, Novartis, Basel, Switzerland.
  • Voytek SB; Preclinical Safety, Novartis, Basel, Switzerland.
  • Devine PJ; Preclinical Safety, Novartis, Cambridge, MA, USA.
  • Kubek-Luck K; Preclinical Safety, Novartis, Cambridge, MA, USA.
  • Claudio N; Preclinical Safety, Novartis, Cambridge, MA, USA.
  • Cordier A; Preclinical Safety, Novartis, Cambridge, MA, USA.
  • Heier A; Preclinical Safety, Novartis, Basel, Switzerland.
  • Kolly C; Preclinical Safety, Novartis, Basel, Switzerland.
  • Hartmann A; Preclinical Safety, Novartis, Basel, Switzerland.
  • Chibout SD; Preclinical Safety, Novartis, Basel, Switzerland.
  • Bouchard P; Preclinical Safety, Novartis, Basel, Switzerland.
  • Trendelenburg C; Preclinical Safety, Novartis, Cambridge, MA, USA.
Arch Toxicol ; 92(5): 1877-1891, 2018 05.
Article em En | MEDLINE | ID: mdl-29556671
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Azetidinas / Compostos de Benzil / Testes de Toxicidade Crônica / Células Endoteliais / Hemangiossarcoma Limite: Animals / Humans / Male Idioma: En Revista: Arch Toxicol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Azetidinas / Compostos de Benzil / Testes de Toxicidade Crônica / Células Endoteliais / Hemangiossarcoma Limite: Animals / Humans / Male Idioma: En Revista: Arch Toxicol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça