Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells.

Rahmani, Mohamed; Nkwocha, Jewel; Hawkins, Elisa; Pei, Xinyan; Parker, Rebecca E; Kmieciak, Maciej; Leverson, Joel D; Sampath, Deepak; Ferreira-Gonzalez, Andrea; Grant, Steven

Rahmani, Mohamed; Nkwocha, Jewel; Hawkins, Elisa; Pei, Xinyan; Parker, Rebecca E; Kmieciak, Maciej; Leverson, Joel D; Sampath, Deepak; Ferreira-Gonzalez, Andrea; Grant, Steven.

Afiliação

Rahmani M; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia. steven.grant@vcuhealth.org mrahmani@sharjah.ac.ae.
Nkwocha J; College of Medicine, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Hawkins E; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.
Pei X; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.
Parker RE; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.
Kmieciak M; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.
Leverson JD; Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.
Sampath D; AbbVie, North Chicago, Illinois.
Ferreira-Gonzalez A; Genentech, South San Francisco, California.
Grant S; Department of Pathology, Virginia Commonwealth University and the Massey Cancer Center, Richmond, Virginia.

Cancer Res ; 78(11): 3075-3086, 2018 06 01.

Article em En | MEDLINE | ID: mdl-29559471

Assuntos

Apoptose/fisiologia; Leucemia Mieloide Aguda/metabolismo; Mitocôndrias/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteína X Associada a bcl-2/metabolismo; Animais; Apoptose/efeitos dos fármacos; Proteínas Reguladoras de Apoptose/metabolismo; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Linhagem Celular Tumoral; Regulação para Baixo/efeitos dos fármacos; Xenoenxertos; Humanos; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Mitocôndrias/efeitos dos fármacos; Pirimidinas/farmacologia; Sulfonamidas/farmacologia; Células U937

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Apoptose / Proteínas Proto-Oncogênicas c-bcl-2 / Fosfatidilinositol 3-Quinases / Proteína X Associada a bcl-2 / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2018 Tipo de documento: Article

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