Cellular Uptake of Gold Nanoparticles Triggered by Host-Guest Interactions.
J Am Chem Soc
; 140(13): 4469-4472, 2018 04 04.
Article
em En
| MEDLINE
| ID: mdl-29562135
ABSTRACT
We describe an approach to regulate the cellular uptake of small gold nanoparticles using supramolecular chemistry. The strategy relies on the functionalization of AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular uptake can be activated in situ through the addition of cationic covalent cages that specifically recognize the fluorescent pyranine dyes and counterbalance the negative charges. The high selectivity and reversibility of the host-guest recognition activates cellular uptake, even in protein-rich biological media, as well as its regulation by rational addition of either cage or pyranine.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha