Atypical chemokine receptors-"chemokine PACMANs" as new therapeutic targets in glomerulonephritis.
Kidney Int
; 93(4): 774-775, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29571448
ABSTRACT
Inflammatory cells are recruited to sites of inflammation by chemokines. Atypical chemokine receptors regulate chemokine gradients, thereby limiting inflammation. In this issue of Kidney International, atypical chemokine receptor 2 knockouts were described to be increasingly susceptible to immune complex-mediated glomerulonephritis. By degrading CCL2, atypical chemokine receptor 2 limited the recruitment of immune cells and myofibroblasts to the renal interstitial compartment. Therefore, not only inflammation, but also fibrosis, was effectively inhibited, making atypical chemokine receptor 2 an attractive therapeutic target in glomerulonephritis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores de Quimiocinas
/
Glomerulonefrite
Limite:
Humans
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Áustria