Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus.
Virology
; 518: 324-327, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29587190
ABSTRACT
Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity. The concentration of sDPP4 in the plasma of MERS patients (474.76⯱â¯108.06â¯ng/ml) was significantly lower than those of healthy controls (703.42⯱â¯169.96â¯ng/ml), but there were no significant differences among the patient groups. Interestingly, plasma levels of IL-10 and EGF were negatively and positively correlated with sDPP4 concentrations, respectively. The sDPP4 levels in sputa were less than 300â¯ng/ml. Viral infection was inhibited by 50% in the presence of more than 8000â¯ng/ml of sDPP4. Therefore, sDPP4 levels in the plasma of MERS patients are significantly reduced below the threshold needed to exert an antiviral effect against MERS-CoV infection.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Plasma
/
Infecções por Coronavirus
/
Dipeptidil Peptidase 4
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2018
Tipo de documento:
Article