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Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity.
Apisornopas, Jutamas; Silalai, Patamawadee; Kasemsuk, Teerapich; Athipornchai, Anan; Sirion, Uthaiwan; Suksen, Kanoknetr; Piyachaturawat, Pawinee; Suksamrarn, Apichart; Saeeng, Rungnapha.
Afiliação
  • Apisornopas J; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • Silalai P; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • Kasemsuk T; Department of Chemistry, Faculty of Science and Technology, Rambhai Barni Rajabhat University, Chanthaburi 22000, Thailand.
  • Athipornchai A; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • Sirion U; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • Suksen K; Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Piyachaturawat P; Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Suksamrarn A; Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
  • Saeeng R; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic address: rungnaph@buu.ac.th.
Bioorg Med Chem Lett ; 28(9): 1558-1561, 2018 05 15.
Article em En | MEDLINE | ID: mdl-29606574
ABSTRACT
New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Verbenaceae / Iridoides / Glicosídeos Iridoides / Glicosídeos / Antineoplásicos Fitogênicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Tailândia
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Verbenaceae / Iridoides / Glicosídeos Iridoides / Glicosídeos / Antineoplásicos Fitogênicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Tailândia