Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.

Ohto, Umeharu; Ishida, Hanako; Shibata, Takuma; Sato, Ryota; Miyake, Kensuke; Shimizu, Toshiyuki

Ohto, Umeharu; Ishida, Hanako; Shibata, Takuma; Sato, Ryota; Miyake, Kensuke; Shimizu, Toshiyuki.

Afiliação

Ohto U; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: umeji@mol.f.u-tokyo.ac.jp.
Ishida H; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Shibata T; Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Sato R; Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Miyake K; Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Shimizu T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: shimizu@mol.f.u-tokyo.ac.jp.

Immunity ; 48(4): 649-658.e4, 2018 04 17.

Article em En | MEDLINE | ID: mdl-29625894

Assuntos

Ilhas de CpG/genética; Proteínas de Ligação a DNA/metabolismo; DNA/metabolismo; Motivos de Nucleotídeos/genética; Receptor Toll-Like 9/genética; Receptor Toll-Like 9/metabolismo; Animais; Sítios de Ligação/genética; Linhagem Celular; DNA/genética; Dimerização; Drosophila; Ativação Enzimática; Células HEK293; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Receptor 7 Toll-Like/genética; Receptor 7 Toll-Like/metabolismo; Receptor 8 Toll-Like/genética; Receptor 8 Toll-Like/metabolismo

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: DNA / Ilhas de CpG / Proteínas de Ligação a DNA / Receptor Toll-Like 9 / Motivos de Nucleotídeos Limite: Animals / Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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