Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of <i>Nf1</i> low-grade glioma growth.

Pan, Yuan; Xiong, Min; Chen, Ran; Ma, Yu; Corman, Courtney; Maricos, Meron; Kindler, Urs; Semtner, Marcus; Chen, Yi-Hsien; Dahiya, Sonika; Gutmann, David H

Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.

Pan, Yuan; Xiong, Min; Chen, Ran; Ma, Yu; Corman, Courtney; Maricos, Meron; Kindler, Urs; Semtner, Marcus; Chen, Yi-Hsien; Dahiya, Sonika; Gutmann, David H.

Afiliação

Pan Y; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Xiong M; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Chen R; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma Y; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Corman C; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Maricos M; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Kindler U; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Semtner M; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Chen YH; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Dahiya S; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Gutmann DH; Genome Engineering and iPSC Center (GEIC), Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Genes Dev ; 32(7-8): 491-496, 2018 04 01.

Article em En | MEDLINE | ID: mdl-29632086

Assuntos

Glioma/imunologia; Microglia/imunologia; Linfócitos T/imunologia; Microambiente Tumoral/imunologia; Animais; Células Cultivadas; Quimiocina CCL5/biossíntese; Quimiocina CCL5/genética; Quimiocina CCL5/fisiologia; Expressão Gênica; Genes da Neurofibromatose 1; Glioma/genética; Glioma/metabolismo; Glioma/patologia; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Nus; Microglia/metabolismo; Microglia/patologia; Receptores CCR2/genética; Receptores CCR2/metabolismo

Palavras-chave

chemokines; monocyte; stroma; tumor microenvironment

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T / Microglia / Microambiente Tumoral / Glioma Limite: Animals Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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