Potentiating tumor immunity using aptamer-targeted RNAi to render CD8<sup>+</sup> T cells resistant to TGFß inhibition.

Puplampu-Dove, Yvonne; Gefen, Tal; Rajagopalan, Anugraha; Muheramagic, Darija; Schrand, Brett; Gilboa, Eli

Potentiating tumor immunity using aptamer-targeted RNAi to render CD8⁺ T cells resistant to TGFß inhibition.

Puplampu-Dove, Yvonne; Gefen, Tal; Rajagopalan, Anugraha; Muheramagic, Darija; Schrand, Brett; Gilboa, Eli.

Afiliação

Puplampu-Dove Y; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Gefen T; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Rajagopalan A; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Muheramagic D; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Schrand B; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Gilboa E; Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, and Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Oncoimmunology ; 7(4): e1349588, 2018.

Article em En | MEDLINE | ID: mdl-29632714

Palavras-chave

Aptamers; Cancer immunotherapy; TGFß; preclinical mouse models; siRNA; tumor targeting

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Oncoimmunology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos