LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Nat Commun
; 9(1): 1488, 2018 04 16.
Article
em En
| MEDLINE
| ID: mdl-29662071
ABSTRACT
Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Receptores Citoplasmáticos e Nucleares
/
Fenalenos
/
Diabetes Mellitus Experimental
/
Células Secretoras de Insulina
/
Hipoglicemiantes
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha