Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles.

Addinsall, Alex B; Wright, Craig R; Shaw, Chris S; McRae, Natasha L; Forgan, Leonard G; Weng, Chia-Heng; Conlan, Xavier A; Francis, Paul S; Smith, Zoe M; Andrikopoulos, Sofianos; Stupka, Nicole

Addinsall, Alex B; Wright, Craig R; Shaw, Chris S; McRae, Natasha L; Forgan, Leonard G; Weng, Chia-Heng; Conlan, Xavier A; Francis, Paul S; Smith, Zoe M; Andrikopoulos, Sofianos; Stupka, Nicole.

Afiliação

Addinsall AB; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria , Australia.
Wright CR; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds, Victoria , Australia.
Shaw CS; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds, Victoria , Australia.
McRae NL; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria , Australia.
Forgan LG; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria , Australia.
Weng CH; Department of Medicine-Austin Health, The University of Melbourne , Heidelberg, Victoria , Australia.
Conlan XA; Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, Victoria , Australia.
Francis PS; Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, Victoria , Australia.
Smith ZM; Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, Victoria , Australia.
Andrikopoulos S; Department of Medicine-Austin Health, The University of Melbourne , Heidelberg, Victoria , Australia.
Stupka N; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria , Australia.

Am J Physiol Regul Integr Comp Physiol ; 315(2): R380-R396, 2018 08 01.

Article em En | MEDLINE | ID: mdl-29668323

Assuntos

Retículo Endoplasmático/enzimologia; Proteínas de Membrana/deficiência; Contração Muscular; Fibras Musculares de Contração Rápida/enzimologia; Força Muscular; Selenoproteínas/deficiência; Adulto; Animais; Composição Corporal; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Estimulação Elétrica; Estresse do Retículo Endoplasmático; Membro Posterior; Humanos; Masculino; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos Knockout; Atividade Motora; Fibras Musculares de Contração Lenta/enzimologia; Selenoproteínas/genética; Selenoproteínas/metabolismo; Tiorredoxinas/genética; Tiorredoxinas/metabolismo; Fator de Transcrição CHOP/genética; Fator de Transcrição CHOP/metabolismo; Adulto Jovem

Palavras-chave

SEPS1; endoplasmic reticulum stress; fast-twitch muscle; selenoprotein S; thioredoxin

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fibras Musculares de Contração Rápida / Retículo Endoplasmático / Selenoproteínas / Força Muscular / Proteínas de Membrana / Contração Muscular Limite: Adult / Animals / Humans / Male Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália

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