InsP<sub>3</sub>R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca<sup>2+</sup> elevation and TBK1 activity.

Yang, Long; Gu, Wenwen; Cheung, King-Ho; Yan, Lan; Tong, Benjamin Chun-Kit; Jiang, Yuanying; Yang, Jun

InsP₃R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca²⁺ elevation and TBK1 activity.

Yang, Long; Gu, Wenwen; Cheung, King-Ho; Yan, Lan; Tong, Benjamin Chun-Kit; Jiang, Yuanying; Yang, Jun.

Afiliação

Yang L; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
Gu W; Jinan Military General Hospital, 25 Shifan Road, Jinan, 250031, China.
Cheung KH; NHFPC Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, 2140 Xie Tu Road, Shanghai, 200032, China.
Yan L; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Tong BC; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
Jiang Y; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Yang J; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. 13761571578@163.com.

BMC Biol ; 16(1): 46, 2018 04 27.

Article em En | MEDLINE | ID: mdl-29703257

Assuntos

Cálcio/metabolismo; Candida albicans/metabolismo; Citosol/metabolismo; Imunidade Inata/fisiologia; Fator Regulador 3 de Interferon/metabolismo; Fagossomos/metabolismo; Proteínas de Transporte Vesicular/metabolismo; Animais; Citoplasma/metabolismo; Células HEK293; Humanos; Interferon Tipo I/metabolismo; Camundongos; Fagocitose/fisiologia

Palavras-chave

Antifungal innate immune response; Exocyst complex component 2 (SEC5); Inositol 1,4,5-trisphosphate receptors (InsP3R); Tank-binding kinase 1 (TBK1)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fagossomos / Candida albicans / Cálcio / Citosol / Proteínas de Transporte Vesicular / Fator Regulador 3 de Interferon / Imunidade Inata Limite: Animals / Humans Idioma: En Revista: BMC Biol Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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