The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.
Annu Rev Neurosci
; 41: 475-499, 2018 07 08.
Article
em En
| MEDLINE
| ID: mdl-29709210
ABSTRACT
Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior that occurs as a one-, two-, or three-phase rhythm. Each breath is assembled stochastically, and increasing evidence suggests that each phase can be generated independently by a dedicated excitatory microcircuit. Within each microcircuit, rhythmicity emerges through three entangled mechanisms ( a) glutamatergic transmission, which is amplified by ( b) intrinsic bursting and opposed by ( c) concurrent inhibition. This rhythmogenic triangle is dynamically tuned by neuromodulators and other network interactions. The ability of coupled oscillators to reconfigure and recombine may allow breathing to remain robust yet plastic enough to conform to nonventilatory behaviors such as vocalization, swallowing, and coughing. Lessons learned from the respiratory network may translate to other highly dynamic and integrated rhythmic systems, if approached one breath at a time.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Periodicidade
/
Respiração
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Encéfalo
/
Modelos Neurológicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Ano de publicação:
2018
Tipo de documento:
Article