Reliable and fast volumetry of the lumbar spinal cord using cord image analyser (Cordial).
Eur Radiol
; 28(11): 4488-4495, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29713776
ABSTRACT
OBJECTIVE:
To validate the precision and accuracy of the semi-automated cord image analyser (Cordial) for lumbar spinal cord (SC) volumetry in 3D T1w MRI data of healthy controls (HC). MATERIALS ANDMETHODS:
40 3D T1w images of 10 HC (w/m 6/4; age range 18-41 years) were acquired at one 3T-scanner in two MRI sessions (time interval 14.9±6.1 days). Each subject was scanned twice per session, allowing determination of test-retest reliability both in back-to-back (intra-session) and scan-rescan images (inter-session). Cordial was applied for lumbar cord segmentation twice per image by two raters, allowing for assessment of intra- and inter-rater reliability, and compared to a manual gold standard.RESULTS:
While manually segmented volumes were larger (mean 2028±245 mm3 vs. Cordial 1636±300 mm3, p<0.001), accuracy assessments between manually and semi-automatically segmented images showed a mean Dice-coefficient of 0.88±0.05. Calculation of within-subject coefficients of variation (COV) demonstrated high intra-session (1.22-1.86%), inter-session (1.26-1.84%), as well as intra-rater (1.73-1.83%) reproducibility. No significant difference was shown between intra- and inter-session reproducibility or between intra-rater reliabilities. Although inter-rater reproducibility (COV 2.87%) was slightly lower compared to all other reproducibility measures, between rater consistency was very strong (intraclass correlation coefficient 0.974).CONCLUSION:
While under-estimating the lumbar SCV, Cordial still provides excellent inter- and intra-session reproducibility showing high potential for application in longitudinal trials. KEY POINTS ⢠Lumbar spinal cord segmentation using the semi-automated cord image analyser (Cordial) is feasible. ⢠Lumbar spinal cord is 40-mm cord segment 60 mm above conus medullaris. ⢠Cordial provides excellent inter- and intra-session reproducibility in lumbar spinal cord region. ⢠Cordial shows high potential for application in longitudinal trials.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Imageamento por Ressonância Magnética
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Imageamento Tridimensional
Limite:
Adolescent
/
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
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