Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1.
J Gerontol A Biol Sci Med Sci
; 74(2): 155-162, 2019 01 16.
Article
em En
| MEDLINE
| ID: mdl-29733330
ABSTRACT
Caloric restriction (CR) is the most potent nonpharmacological intervention known to both protect against carcinogenesis and delay aging in laboratory animals. There is a growing number of anticarcinogens and CR mimetics that activate NAD(P)Hquinone oxidoreductase 1 (NQO1). We have previously shown that NQO1, an antioxidant enzyme that acts as an energy sensor through modulation of intracellular redox and metabolic state, is upregulated by CR. Here, we used NQO1-knockout (KO) mice to investigate the role of NQO1 in both the aging process and tumor susceptibility, specifically in the context of CR. We found that NQO1 is not essential for the beneficial effects of CR on glucose homeostasis, physical performance, metabolic flexibility, life-span extension, and (unlike our previously observation with Nrf2) chemical-induced tumorigenesis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Composição Corporal
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NAD(P)H Desidrogenase (Quinona)
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Estresse Oxidativo
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Restrição Calórica
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Longevidade
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Neoplasias Experimentais
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Gerontol A Biol Sci Med Sci
Assunto da revista:
GERIATRIA
Ano de publicação:
2019
Tipo de documento:
Article