Epistatic interaction of apolipoprotein E and lipolysis-stimulated lipoprotein receptor genetic variants is associated with Alzheimer's disease.
Neurobiol Aging
; 69: 292.e1-292.e5, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-29858039
ABSTRACT
The ε4 allele of the apolipoprotein E (APOE) gene common polymorphism is the strongest genetic risk factor for Alzheimer's disease (AD). Human APOE gene is located on chromosome 19q13.1, a region linked to AD that also includes the LSR gene, which encodes the lipolysis-stimulated lipoprotein receptor (LSR). As an APOE receptor, LSR is involved in the regulation of lipid homeostasis in both periphery and brain. This study aimed to determine the potential interactions between 2 LSR genetic variants, rs34259399 and rs916147, and the APOE common polymorphism in 142 AD subjects (mean age 73.16 ± 8.50 years) and 63 controls (mean age 70.41 ± 8.49 years). A significant epistatic interaction was observed between APOE and both LSR variants, rs34259399 (beta = -0.95; p = 2 × 10-5) and rs916147 (beta = -0.83; p = 6.8 × 10-3). Interestingly, the interaction of LSR polymorphisms with APOE non-ε4 alleles increased AD risk. This indicates the existence of complex molecular interactions between these 2 neighboring genes involved in the pathogenesis of AD, which merits further investigation.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Receptores de Lipoproteínas
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Epistasia Genética
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Doença de Alzheimer
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França