Protein Clusters in Phosphotyrosine Signal Transduction.
J Mol Biol
; 430(22): 4547-4556, 2018 10 26.
Article
em En
| MEDLINE
| ID: mdl-29870724
ABSTRACT
Signal transduction systems based on tyrosine phosphorylation are central to cell-cell communication in multicellular organisms. Typically, in such a system, the signal is initiated by activating tyrosine kinases associated with transmembrane receptors, which induces tyrosine phosphorylation of the receptor and/or associated proteins. The phosphorylated tyrosines then serve as docking sites for the binding of various downstream effector proteins. It has long been observed that the cooperative association of the receptors and effectors produces higher-order protein assemblies (clusters) following signal activation in virtually all phosphotyrosine signal transduction systems. However, mechanistic studies on how such clustering processes affect signal transduction outcomes have only emerged recently. Here we review current progress in decoding the biophysical consequences of clustering on the behavior of the system, and how clustering affects how these receptors process information.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Fosfotirosina
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Complexos Multiproteicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Mol Biol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos