Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine.
Childs Nerv Syst
; 34(11): 2321-2324, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-29872899
ABSTRACT
Histiocytosis is a heterogeneous group of disease entities, comprised by two main categories, namely Langerhans and non-Langerhans cell histiocytoses. Central nervous system involvement in histiocytosis is considered very rare and is often secondary to affection of anatomically related bone structures and/or multi-organ disease. We present a never-before described case of rare childhood histiocytosis with hybrid features of Langerhans cell histiocytosis and juvenile xanthogranuloma confined to the central nervous system in a 2- and a half-year-old boy with distinct treatment response to clofarabine. The case also emphasizes the diagnostic significance of stereotactic brain biopsy.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Histiocitose
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Doenças do Sistema Nervoso Central
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Clofarabina
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Antimetabólitos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Child, preschool
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Humans
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Male
Idioma:
En
Revista:
Childs Nerv Syst
Assunto da revista:
NEUROLOGIA
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PEDIATRIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Dinamarca