A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals.

Xie, Zhenda; Yin, Biao; Shen, Jiajie; Hong, Danqi; Zhu, Liquan; Ge, Jingyan; Zhu, Qing

Xie, Zhenda; Yin, Biao; Shen, Jiajie; Hong, Danqi; Zhu, Liquan; Ge, Jingyan; Zhu, Qing.

Afiliação

Xie Z; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
Yin B; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
Shen J; Key Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine Zhejiang University, Xueshi Road 1, Hangzhou 310006, China.
Hong D; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
Zhu L; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
Ge J; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
Zhu Q; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, ChaowangRoad 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.

Org Biomol Chem ; 16(25): 4628-4632, 2018 07 07.

Article em En | MEDLINE | ID: mdl-29901667

ABSTRACT

ABSTRACT

In this study, a single fluorescent probe (DPFP) containing a 1,8-naphthalimide dye and a homoallylamino group for imaging pH and formaldehyde (FA) has been developed that exhibits significant blue fluorescence (λem at 455 nm) under acidic pH conditions (pH < 7.0) and green fluorescence (λem at 555 nm) in the presence of FA, respectively. Furthermore, probe DPFP was successfully applied to image acidic lysosomes and exogenous or endogenous FA in living HeLa cells.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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