Ventilation inhomogeneity in infants with recurrent wheezing.
Thorax
; 73(10): 936-941, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-29907664
ABSTRACT
BACKGROUND:
The care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing.OBJECTIVE:
To assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls.METHODS:
This is a case-control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study. All infants, at a time of clinical stability, underwent functional assessment including multiple breath washout, forced expiratory flows and body plethysmography.RESULTS:
LCI z-score values among infants with recurrent wheeze were 0.84 units (95% CI 0.41 to 1.26) higher than healthy infants (mean (95% CI) 0.26 (-0.11 to 0.63) vs -0.58 (-0.79 to 0.36), p<0.001)). Nineteen percent of recurrently wheezing infants had LCI values that were above the upper limit of normal (>1.64 z-scores). Elevated exhaled nitric oxide, but not symptoms, was associated with abnormal LCI values in infants with recurrent wheeze (p=0.05).CONCLUSIONS:
Ventilation inhomogeneity is present in clinically stable infants with recurrent wheezing.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Testes de Função Respiratória
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Asma
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Sons Respiratórios
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Pulmão
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Thorax
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá