Therapy of aseptic nonunions with parathyroid hormone.
Eur J Orthop Surg Traumatol
; 29(1): 169-173, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-29931529
ABSTRACT
The absence of osseous consolidation of a fracture for 9 or more months with no potential to heal is defined as nonunion. Both for the patient and from a socioeconomic point of view, nonunions represent a major problem. Hypertrophic, vital nonunions are distinguished from atrophic avital ones. Risk factors for a delayed fracture healing are insufficient immobilisation, poor adaptation of the fracture surfaces or residual instability, interposition of soft tissue within the fracture gap, as well as circulation disturbances and infections. The incidence of nonunions after fractures of the long bones lies between 2.6 and 16% depending on the surgical technique used. In human and animal studies, a positive effect of parathyroid hormone (PTH) on fracture healing has been shown. PTH has a direct stimulatory effect on osteoblasts and osteoclasts. In addition, it appears to influence the effect of osseous growth factors. In this prospective study, 32 patients with nonunions were treated with teriparatide to investigate the effects of PTH on fracture healing. Definitive healing of the nonunions following PTH treatment could be observed in 95% of the cases.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Consolidação da Fratura
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Teriparatida
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Conservadores da Densidade Óssea
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Fraturas não Consolidadas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Orthop Surg Traumatol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha