Effect of Lower Versus Higher Protein Content in Infant Formula Through the First Year on Body Composition from 1 to 6 Years: Follow-Up of a Randomized Clinical Trial.
Obesity (Silver Spring)
; 26(7): 1203-1210, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29932518
ABSTRACT
OBJECTIVE:
The objective of this study was to investigate the effect of lower protein (LP) versus higher protein (HP) content in infant formula on body composition from 3 months to 6 years.METHODS:
In a multicenter, double-blind European trial, healthy infants (N = 1,090) were randomly assigned to different protein content formulas (upper [HP] and lower [LP] limits of the European Union regulations in 2001) during the first year; breastfed infants (N = 588) were recruited for reference values. Weight, height, and triceps and subscapular skinfold (SF) thickness were measured repeatedly (N = 650 at 6 years), and body composition was estimated (Slaughter). The 99th percentile of fat mass index reference data were used to assess excess body fat at 6 years.RESULTS:
At 2 and 6 years, the study observed greater sum of SFs (Δ 2 years 0.5 mm, P = 0.026, Δ 6 years 0.6 mm, P = 0.045), fat mass index (Δ 2 years 0.12 kg/m², P = 0.008, Δ 6 years 0.15 kg/m², P = 0.011), and fat-free mass index (Δ 2 years 0.17 kg/m², P = 0.003, Δ 6 years 0.18 kg/m², P = 0.010) in the HP group compared with the LP group. At 6 years, the HP group had a twofold higher risk than the LP group for excess body fat (adjusted odds ratio 2.13, P = 0.019).CONCLUSIONS:
Infant formula with HP levels induced greater fat mass in children from 2 to 6 years. Lowering the protein content of infant formula may result in a healthier body composition in early childhood.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Composição Corporal
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Desenvolvimento Infantil
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Dieta com Restrição de Proteínas
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Fórmulas Infantis
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Dieta Rica em Proteínas
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Obesity (Silver Spring)
Assunto da revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha