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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Intlekofer, Andrew M; Shih, Alan H; Wang, Bo; Nazir, Abbas; Rustenburg, Ariën S; Albanese, Steven K; Patel, Minal; Famulare, Christopher; Correa, Fabian M; Takemoto, Naofumi; Durani, Vidushi; Liu, Hui; Taylor, Justin; Farnoud, Noushin; Papaemmanuil, Elli; Cross, Justin R; Tallman, Martin S; Arcila, Maria E; Roshal, Mikhail; Petsko, Gregory A; Wu, Bin; Choe, Sung; Konteatis, Zenon D; Biller, Scott A; Chodera, John D; Thompson, Craig B; Levine, Ross L; Stein, Eytan M.
Afiliação
  • Intlekofer AM; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Shih AH; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wang B; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Nazir A; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Rustenburg AS; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Albanese SK; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Patel M; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Famulare C; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Correa FM; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Takemoto N; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Durani V; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Liu H; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Taylor J; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Farnoud N; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Papaemmanuil E; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Cross JR; Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Tallman MS; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Arcila ME; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Roshal M; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Petsko GA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wu B; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Choe S; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Konteatis ZD; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Biller SA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Chodera JD; The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Thompson CB; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Levine RL; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Stein EM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature ; 559(7712): 125-129, 2018 07.
Article em En | MEDLINE | ID: mdl-29950729
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Triazinas / Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Proteínas Mutantes / Multimerização Proteica / Aminopiridinas / Isocitrato Desidrogenase / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Triazinas / Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Proteínas Mutantes / Multimerização Proteica / Aminopiridinas / Isocitrato Desidrogenase / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos