Genetic and metabolic hallmarks of clear cell renal cell carcinoma.
Biochim Biophys Acta Rev Cancer
; 1870(1): 23-31, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29959988
ABSTRACT
Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by deregulated hypoxia-inducible factor signaling, mutation of several key chromatin modifying enzymes, and numerous alterations in cellular metabolism. Pre-clinical studies have historically been limited to cell culture models, however, the identification of critical tumor suppressors and oncogenes from large-scale patient sequencing data has led to several new genetically engineered mouse models with phenotypes reminiscent of ccRCC. In this review, we summarize recent literature on these topics and discuss how they inform targeted therapeutic approaches for the treatment of ccRCC.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Neoplasias Renais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos