Epstein-Barr Virus Positive Mucocutaneous Ulcer: A Case Report.
S D Med
; 71(6): 252-255, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-30005148
ABSTRACT
Epstein-Barr virus (EBV) is known to be associated with B-cell lymphoproliferative disorders, and EBV-positive mucocutaneous ulcer (EBV-MCU) is a recently described entity observed in immunocompromised individuals. EBV-MCU is an aggressive appearing ulcerated lesion seen in the skin, oral cavity, and gastrointestinal tract. The process has Hodgkin-like features with a self-limited, indolent course, generally responding well to conservative management. We present a case of EBV-MCU recently encountered in a 54-year-old renal transplant recipient. She had persistent rectal pain and bleeding for over a year following hemorroidectomy. A large ulcer in the distal rectum with excoriation and granular margins was noted on examination, and an initial biopsy from the lesion was inconclusive. A repeat biopsy demonstrated ulcerated squamous and colonic mucosa with a polymorphic lymphoid infiltrate in the submucosa that contained large atypical cells. The large atypical cells were positive for PAX-5 and CD30 and demonstrated EBV RNA by in situ hybridization. EBV-MCU is a recently described occurrence in transplant patients, and awareness of this recently described entity is necessary for appropriate diagnosis and treatment.
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Bases de dados:
MEDLINE
Assunto principal:
Úlcera
/
Herpesvirus Humano 4
/
Infecções por Vírus Epstein-Barr
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
S D Med
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article