Antagonising Wnt/ß-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

Hombrebueno, Jose R; Ali, Imran H A; Ma, Jian-Xing; Chen, Mei; Xu, Heping

Hombrebueno, Jose R; Ali, Imran H A; Ma, Jian-Xing; Chen, Mei; Xu, Heping.

Afiliação

Hombrebueno JR; Centre for Experimental Medicine, Wellcome-Wolfson Institute of Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. j.romero@qub.ac.uk.
Ali IHA; Centre for Experimental Medicine, Wellcome-Wolfson Institute of Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Ma JX; Department of Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Chen M; Centre for Experimental Medicine, Wellcome-Wolfson Institute of Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. m.chen@qub.ac.uk.
Xu H; Centre for Experimental Medicine, Wellcome-Wolfson Institute of Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. heping.xu@qub.ac.uk.

Diabetologia ; 61(11): 2433-2446, 2018 11.

Article em En | MEDLINE | ID: mdl-30019207

Assuntos

Extração de Catarata/efeitos adversos; Retinopatia Diabética/etiologia; Retinopatia Diabética/metabolismo; Degeneração Retiniana/etiologia; Degeneração Retiniana/metabolismo; Animais; Diabetes Mellitus Experimental/complicações; Retinopatia Diabética/patologia; Modelos Animais de Doenças; Eletrorretinografia; Immunoblotting; Imuno-Histoquímica; Insulina/genética; Insulina/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Degeneração Retiniana/patologia

Palavras-chave

Cataract surgery; Diabetic retinopathy; Electroretinography; Inflammation; Ins2 Akita; Neurodegeneration; SD-OCT

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Degeneração Retiniana / Extração de Catarata / Retinopatia Diabética Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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