Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.

Nigam, Richa; Babu, Kaki Raveendra; Ghosh, Topi; Kumari, Bhavini; Akula, Deepa; Rath, Subha Narayan; Das, Prolay; Anindya, Roy; Khan, Faiz Ahmed

Nigam, Richa; Babu, Kaki Raveendra; Ghosh, Topi; Kumari, Bhavini; Akula, Deepa; Rath, Subha Narayan; Das, Prolay; Anindya, Roy; Khan, Faiz Ahmed.

Afiliação

Nigam R; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Babu KR; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Ghosh T; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Kumari B; Department of Chemistry, Indian Institute of Technology Patna, Bihar, Patna 801106, India.
Akula D; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Rath SN; Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Das P; Department of Chemistry, Indian Institute of Technology Patna, Bihar, Patna 801106, India.
Anindya R; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India. Electronic address: anindya@iith.ac.in.
Khan FA; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India. Electronic address: faiz@iith.ac.in.

Bioorg Med Chem ; 26(14): 4100-4112, 2018 08 07.

Article em En | MEDLINE | ID: mdl-30041948

Assuntos

Homólogo AlkB 3 da Dioxigenase Dependente de alfa-Cetoglutarato/antagonistas & inibidores; Indenos/farmacologia; Homólogo AlkB 3 da Dioxigenase Dependente de alfa-Cetoglutarato/metabolismo; Calorimetria; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Humanos; Indenos/síntese química; Indenos/química; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

AlkBH3; DNA repair; Dioxygenase; Indenone; Suzuki-Miyaura cross-coupling

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Homólogo AlkB 3 da Dioxigenase Dependente de alfa-Cetoglutarato / Indenos Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia

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