Exercise activates the hypothalamic S1PR1-STAT3 axis through the central action of interleukin 6 in mice.
J Cell Physiol
; 233(12): 9426-9436, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30063084
ABSTRACT
Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate the role of interleukin 6 (IL-6) associated with acute physical exercise in the control of the hypothalamic S1PR1-signal transducer and activator of transcription 3 (STAT3) axis. Acute exercise session and an intracerebroventricular IL-6 injection increased S1PR1 protein content and STAT3 phosphorylation in the hypothalamus of lean and obese mice accompanied by a reduction in food consumption. Transcriptome analysis indicated a strong positive correlation between Il-6 and S1pr1 messenger RNA in several tissues of genetically diverse BXD mice strains and humans, including in the hypothalamus. Interestingly, exercise failed to stimulate the S1PR1-STAT3 axis in IL-6 knockout mice and the disruption of hypothalamic-specific IL-6 action blocked the anorexigenic effects of exercise. Taken together, our results indicate that physical exercise modulates the S1PR1 protein content in the hypothalamus, through the central action of IL-6.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
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Transdução de Sinais
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Interleucina-6
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Receptores de Lisoesfingolipídeo
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Fator de Transcrição STAT3
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Hipotálamo
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
J Cell Physiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Brasil