Human T cells modulate myeloid-derived suppressor cells through a TNF-α-mediated mechanism.
Immunol Lett
; 202: 31-37, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30076856
ABSTRACT
Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of suppressing T-cell responses in cancer and chronic inflammation. While the effect of MDSC on T cells has been defined thoroughly, the reciprocal impact of T cells on MDSC homeostasis remains poorly understood. Therefore, we comprehensively analyzed the effect of different T-cell subsets on the generation and survival of human MDSC. Using an in vitro MDSC generation assay, we demonstrate that unstimulated CD4+, but not CD8+ T cells, induce polymorphonuclear MDSC (PMN-MDSC) from CD33+ myeloid cells. This effect was dependent on direct cell-cell contact and required TNF-α signaling. Soluble TNF-α was dispensable for PMN-MDSC generation, suggesting that transmembrane TNF-α is involved in that trans-cellular process. Stimulated human CD3+ T cells delayed the apoptosis of PMN-MDSC, which was independent of TNF-α signaling or direct cell-cell contact, but was recapitulated by IL-2. Taken together, our study shows that human T cells modulate MDSC generation and survival through two distinct mechanisms and thereby fine-tune the homeostasis of human MDSC in a regulated manner.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Fator de Necrose Tumoral alfa
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Linfócitos T CD8-Positivos
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Células Mieloides
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Células Supressoras Mieloides
Limite:
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha