Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.
J Radioanal Nucl Chem
; 317(2): 977-984, 2018.
Article
em En
| MEDLINE
| ID: mdl-30100651
ABSTRACT
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Radioanal Nucl Chem
Ano de publicação:
2018
Tipo de documento:
Article