A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma.

Chetty, Anne; Sharda, Azeem; Warburton, Rod; Weinberg, Ellen O; Dong, Jinghui; Fang, Min; Sahagian, G Gary; Chen, Tiangmeng; Xue, Chang; Castellot, John J; Haydon, Philip G; Nielsen, Heber C

Chetty, Anne; Sharda, Azeem; Warburton, Rod; Weinberg, Ellen O; Dong, Jinghui; Fang, Min; Sahagian, G Gary; Chen, Tiangmeng; Xue, Chang; Castellot, John J; Haydon, Philip G; Nielsen, Heber C.

Afiliação

Chetty A; Department of Pediatrics, Tufts Medical Center, Boston, MA, USA, Heber.nielsen@tufts.edu.
Sharda A; Department of Pediatrics, Tufts Medical Center, Boston, MA, USA, Heber.nielsen@tufts.edu.
Warburton R; Department of Medicine, Tufts Medical Center, Boston, MA, USA.
Weinberg EO; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Dong J; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Fang M; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Sahagian GG; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Chen T; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Xue C; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Castellot JJ; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Haydon PG; Graduate Program in Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA, USA, Heber.nielsen@tufts.edu.
Nielsen HC; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.

J Asthma Allergy ; 11: 159-171, 2018.

Article em En | MEDLINE | ID: mdl-30122959

Palavras-chave

GC021109; P2Y6 receptors; airway smooth muscle; cytokines; inflammation; pulmonary function

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Asthma Allergy Ano de publicação: 2018 Tipo de documento: Article