The role of IFN in the development of NAFLD and NASH.
Cytokine
; 124: 154519, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-30139548
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Interferon Tipo I
/
Interferons
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Hepatopatia Gordurosa não Alcoólica
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Fígado
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Dinamarca